Long QT syndrome in children.

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Long QT Syndrome in Children

he advent of genetic testing and the implantable ardioverter-defibrillator (ICD) have so revolutionized the utlook for patients with long QT that the cardiac commuity needs to revise its thinking about long QT syndrome LQTS). This is the underlying message of a report by theridge et al. (1) in this issue of the Journal. Etheridge et al. (1) studied 128 children with LQTS. bout one-half of their...

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Long QT syndrome in children.

T o those of us who were practicing cardiology in the early 1960s, the reports from Jervell and Lange-Nielsen,1 Romano and colleagues,2 and Ward3 were welcome enlightenment for a few of our patients with alarming episodes of syncope and a family history of sudden death. Although Ward reported that one of his original patients responded to ,8-blockade and that form of therapy remains central to ...

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KCNE1 and KCNE2 variants in Patients with Long QT Syndrome

Introduction: Long QT syndrome (LQTS) is a type of ventricular arrhythmia characterized by prolonged QT intervals on electrocardiogram or delay in ventricular repolarization and it can lead to syncope, seizure and sudden cardiac death. Here, KCNE1 and KCNE2 variants are studied among Iranian affected families with this syndrome. Materials and Methods: Fifty patients referring to Rajaei Cardiov...

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Long QT syndrome in children with congenital deafness.

The Jervell and Lange Nielson syndrome(JLN) is an infrequent form of long QT syndrome (LQTS) in which prolonged QT interval and congenital deafness exist together. We attempted to identify patients with LQTS among 127 children (age 1.2 to 10 years) with congenital hearing loss. The corrected QT interval was measured from 12 lead electrocardiogram(ECG) , using Bazettes and Friedricia formulae.Th...

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Long QT Syndrome

Background. Erythromycin is known to prolong ventricular repolarization and has been associated with the occurrence of torsades de pointes. In this study, we have investigated potential mechanisms in vivo and in vitro for induction of an acquired long QT syndrome by erythromycin. Methods and Results. Ventricular electrograms and endocardial monophasic action potentials were recorded in anesthet...

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ژورنال

عنوان ژورنال: Circulation

سال: 1994

ISSN: 0009-7322,1524-4539

DOI: 10.1161/circ.89.1.8281689